Infection of Endothelial Cells with Acinetobacter baumannii Reveals Remodelling of Mitochondrial Protein Complexes

Author:

Leukert Laura1,Tietgen Manuela12,Krause Felix F.13,Schultze Tilman G.1,Fuhrmann Dominik C.4,Debruyne Charline5,Salcedo Suzana P.5ORCID,Visekruna Alexander3,Wittig llka6,Göttig Stephan1ORCID

Affiliation:

1. Institute for Medical Microbiology and Infection Control, University Hospital, Goethe University, Frankfurt am Main, Germany

2. University Center of Competence for Infection Control of the State of Hesse, Frankfurt am Main, Germany

3. Institute for Medical Microbiology and Hygiene, Philipps-University, Marburg, Germany

4. Institute of Biochemistry I, Faculty of Medicine, Goethe University, Frankfurt am Main, Germany

5. Laboratory of Molecular Microbiology and Structural Biochemistry, Centre National de la Recherche Scientifique UMR5086, Université de Lyon, Lyon, France

6. Functional Proteomics, Institute of Cardiovascular Physiology, Goethe University, Frankfurt am Main, Germany

Abstract

Virulence traits of Acinetobacter baumannii isolates of the worldwide most prevalent international clonal lineage, IC2, remain largely unknown. In our study, multidrug-resistant IC2 clinical isolates differed substantially in their virulence potential despite their close genetic relatedness.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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