Clostridium butyricum and Its Derived Extracellular Vesicles Modulate Gut Homeostasis and Ameliorate Acute Experimental Colitis-Reference-Cited by-同舟云学术

Clostridium butyricum and Its Derived Extracellular Vesicles Modulate Gut Homeostasis and Ameliorate Acute Experimental Colitis

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Ma Lingyan¹,Shen Qicheng²,Lyu Wentao¹,lv Lu¹,Wang Wen¹,Yu Minjie¹,Yang Hua¹,Tao Shiyu³^ORCID,Xiao Yingping¹^ORCID

Affiliation:

1. State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou, China

2. College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China

3. College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, China

Abstract

This study indicated that C. butyricum provided a prevention effect against colitis mice, which involved protection of the intestinal barrier and positively regulating gut microbiota. Furthermore, we confirmed that the gut microbiota and metabolites that were induced by C. butyricum also contributed to the attenuation of DSS-induced colitis. Importantly, C. butyricum -derived EVs showed an effective impact in alleviating colitis.

Funder

China Postdoctoral Science Foundation

National Natural Science Foundation of China

State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01368-22

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