Systematic Microbiome Dysbiosis Is Associated with IgA Nephropathy

Author:

Cai Fengtao12,Zhou Chenfen3,Jiao Na4,Liang Xinling2,Ye Zhiming2,Chen Wei5,Yang Qiongqiong6,Peng Hui7,Tang Ying8,Niu Chaoqun3,Zhao Guoping39,Wang Zefeng310,Zhang Guoqing3,Yu Xueqing1211ORCID

Affiliation:

1. School of Medicine, South China University of Technology, Guangzhou, China

2. Department of Nephrology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China

3. National Genomics Data Center & Bio-Med Big Data Center, CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

4. National Clinical Research Center for Child Health, the Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

5. Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

6. Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

7. Department of Nephrology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

8. Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China

9. Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China

10. CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China

11. Guangdong-Hong Kong Joint Laboratory on Immunological and Genetic Kidney Diseases, Guangzhou, China

Abstract

This study provides microbial profiles of IgAN across multiple niches and underlines the potential of these biomarkers as promising, noninvasive tools with which to differentiate IgAN patients for clinical applications.

Funder

Guangdong-Hong Kong-Macao-Joint Labs Program from Guangdong Science Technology

National Key R&D Program of China

MOST | National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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