Daily SARS-CoV-2 Nasal Antigen Tests Miss Infected and Presumably Infectious People Due to Viral Load Differences among Specimen Types-Reference-Cited by-同舟云学术

Daily SARS-CoV-2 Nasal Antigen Tests Miss Infected and Presumably Infectious People Due to Viral Load Differences among Specimen Types

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Viloria Winnett Alexander¹,Akana Reid¹,Shelby Natasha¹^ORCID,Davich Hannah¹^ORCID,Caldera Saharai¹,Yamada Taikun²³,Reyna John Raymond B.²,Romano Anna E.¹,Carter Alyssa M.¹,Kim Mi Kyung¹,Thomson Matt¹,Tognazzini Colten⁴^ORCID,Feaster Matthew⁴^ORCID,Goh Ying-Ying⁴,Chew Yap Ching²³,Ismagilov Rustem F.¹^ORCID

Affiliation:

1. California Institute of Technology, Pasadena, California, USA

2. Pangea Laboratory LLC, Tustin, California, USA

3. Zymo Research Corporation, Irvine, California, USA

4. Pasadena Public Health Department, Pasadena, California, USA

Abstract

We reveal three findings from a longitudinal study of daily nasal antigen rapid diagnostic test (Ag-RDT) evaluated against SARS-CoV-2 viral load quantification in three specimen types (saliva, nasal swab, and throat swab) in participants enrolled at the incidence of infection. First, the evaluated Ag-RDT showed low (44%) clinical sensitivity for detecting infected persons at all infection stages.

Funder

CIT | Linde Center, California Institute of Technology

Jacobs Institute for Molecular Engineering for Medicine, Caltech

UCLA DGSOM Geffen Fellowship

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01295-23

Reference63 articles.

1. World Health Organization. 2021. Antigen-detection in the diagnosis of SARS-CoV-2 infection (interim guidance). https://www.who.int/publications/i/item/antigen-detection-in-the-diagnosis-of-sars-cov-2infection-using-rapid-immunoassays. Accessed 6 October 2021.

2. Rapid Diagnostic Testing for SARS-CoV-2

3. Use of At-Home COVID-19 Tests — United States, August 23, 2021–March 12, 2022

4. The Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19: Antigen Testing

5. Strategies for Using Antigen Rapid Diagnostic Tests to Reduce Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in Low- and Middle-Income Countries: A Mathematical Modelling Study Applied to Zambia

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Double testing with lateral flow antigen test devices for COVID-19: does a second test in quick succession add value?;Journal of Virological Methods;2024-09

2. Validating Combination Throat-Nasal Swab Specimens for Coronavirus Disease 2019 Tests Would Improve Early Detection, Especially for the Most Vulnerable;Clinical Infectious Diseases;2024-07-23

3. Impact of Swabbing Location, Self-Swabbing, and Food Intake on SARS-CoV-2 RNA Detection;Microorganisms;2024-03-15

4. Within-host evolutionary dynamics and tissue compartmentalization during acute SARS-CoV-2 infection;Journal of Virology;2024-01-23

5. The Impact of Repeating COVID-19 Rapid Antigen Tests on Prevalence Boundary Performance and Missed Diagnoses;Diagnostics;2023-10-16