Exogenously Scavenged and Endogenously Synthesized Heme Are Differentially Utilized by Mycobacterium tuberculosis

Author:

Donegan Rebecca K.12,Fu Yibo1,Copeland Jacqueline3,Idga Stanzin4ORCID,Brown Gabriel1,Hale Owen F.5ORCID,Mitra Avishek6ORCID,Yang Hui7,Dailey Harry A.89,Niederweis Michael6ORCID,Jain Paras310ORCID,Reddi Amit R.1511ORCID

Affiliation:

1. School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA

2. Department of Chemistry, Barnard College, New York, New York, USA

3. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA

4. Department of Pathology, Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, New York, USA

5. School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA

6. Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA

7. Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA

8. Department of Microbiology, University of Georgia, Athens, Georgia, USA

9. Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA

10. Cell Therapy and Cell Engineering Laboratory, Memorial Sloan Kettering Cancer Center, New York, New York, USA

11. Parker Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia, USA

Abstract

Mycobacterium tuberculosis infects ~25% of the world’s population and causes tuberculosis (TB), the second leading cause of death from infectious disease. Heme is an essential metabolite for M. tuberculosis , and targeting the unique heme biosynthetic pathway of M. tuberculosis could serve as an effective therapeutic strategy.

Funder

HHS | National Institutes of Health

National Science Foundation

Stony Wold-Herbert Fund

Burroughs Wellcome Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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