High-Density Lipoprotein Cholesterol as a Potential Medium between Depletion of Lachnospiraceae Genera and Hypertension under a High-Calorie Diet

Author:

Lan Yongmei1,Ning Kang2,Ma Yanqing1,Zhao Jin1,Ci Caihong1,Yang Xiao3,An Fulong3,Zhang Zilong1,An Yan1,Cheng Mingyue2ORCID

Affiliation:

1. Key Laboratory of Environmental Ecology and Population Health in Northwest Minority Areas, Department of Medicine, Northwest Minzu University, Lanzhou, China

2. Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular Imaging, Center of AI Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China

3. Department of Internal Medicine, Department of Surgery, People’s Hospital of Sunan County, Zhangye, China

Abstract

Dietary nutrients can be converted by the gut microbiota into metabolites such as short-chain fatty acids, which may serve as disease-preventing agents in hypertension. Due to the limited population mobility and unique high-calorie dietary habits, the cohort of this study can serve as a representative cohort for elucidating the associations between the gut microbiota and hypertension under a high-calorie diet.

Funder

Innovation Team Training Project of Northwest Minzu University of Central Universities Basic Research Funds

Key Project of Northwest Minzu University of Central Universities Basic Research Funds

National Natural Science Foundation of China

National Key R&D Program of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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