The Role of Regulator Catabolite Control Protein A (CcpA) in Streptococcus agalactiae Physiology and Stress Response-Reference-Cited by-同舟云学术

The Role of Regulator Catabolite Control Protein A (CcpA) in Streptococcus agalactiae Physiology and Stress Response

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Roux Anne-Emmanuelle¹^ORCID,Robert Sylvie¹,Bastat Mathilde¹,Rosinski-Chupin Isabelle²,Rong Vanessa¹,Holbert Sébastien¹,Mereghetti Laurent¹³,Camiade Emilie¹^ORCID

Affiliation:

1. ISP, Université de Tours, INRAE, Tours, France

2. Unité Écologie et Évolution de la Résistance aux Antibiotiques, CNRS UMR3525, Institut Pasteur, Paris, France

3. CHRU Tours, Service de Bactériologie-Virologie-Hygiène, Tours, France

Abstract

Streptococcus agalactiae is a major cause of disease burden leading to morbidity and mortality in neonates worldwide. Deciphering its adaptation mechanisms is essential to understand how this bacterium manages to colonize its host. Here, we determined the regulon of the pleiotropic regulator CcpA in S. agalactiae . Our findings reveal that CcpA is not only involved in carbon catabolite repression, but is also important for acidic and oxidative stress resistance and survival in macrophages.

Funder

University of Tours

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02080-22

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