Bacterial Lipoproteins Shift Cellular Metabolism to Glycolysis in Macrophages Causing Bone Erosion-Reference-Cited by-同舟云学术

Bacterial Lipoproteins Shift Cellular Metabolism to Glycolysis in Macrophages Causing Bone Erosion

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Nguyen Minh-Thu¹^ORCID,Hu Zhicheng²³^ORCID,Mohammad Majd³^ORCID,Schöttler Hannah⁴,Niemann Silke¹,Schultz Michelle³,Barczyk-Kahlert Katarzyna⁵,Jin Tao³^ORCID,Hayen Heiko⁴^ORCID,Herrmann Mathias¹

Affiliation:

1. Institute of Medical Microbiology, University Hospital Münster, Münster, Germany

2. Center for Clinical Laboratories, The Affiliated Hospital of Guizhou Medical University, Guiyang, China

3. Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

4. Institute of Inorganic and Analytical Chemistry, University of Münster, Münster, Germany

5. Institute of Immunology, University of Münster, Münster, Germany

Abstract

Osteomyelitis caused by S. aureus is a severe infection of the bone, typically associated with severe bone function impairment, therapeutic failure, high morbidity, invalidity, and occasionally even death. The hallmark of staphylococcal osteomyelitis is the destruction of the cortical bone structures, yet the mechanisms contributing to this pathology are hitherto poorly understood.

Funder

Innovative Medizinische Forschung

Swedish Medical Research Council

Swedish State Under the Agreement between Swedish Government and the County Councils

E och K.G. Lennanders stipendiestiftelse

Sahlgrenska University Hospitals Foundations

Rune och Ulla Amlövs Stiftelse för Neurologisk, Reumatologisk och Audiologisk Forskning

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology