Rapid Evaluation of Vaccine Booster Effectiveness against SARS-CoV-2 Variants

Author:

Cheng Hoi Lok1,Lim Sing Mei1,Jia Huan1,Chen Ming Wei2,Ng Say Yong1,Gao Xiaohong2,Somani Jyoti3,Sengupta Sharmila3,Tay Dousabel M. Y.4,Chua Patrina W. L.1,R. Abirami1,Ling Sharon Y. H.1,McBee Megan E.1,Young Barnaby E.567,Sikes Hadley D.14,Preiser Peter R.2ORCID

Affiliation:

1. Singapore-MIT Alliance in Research and Technology, Singapore

2. School of Biological Sciences, Nanyang Technological University, Singapore

3. National University Hospital, Singapore, Singapore

4. Department of Chemical Engineering, Massachusetts Institute of Technology, USA

5. National Centre for Infectious Diseases, Singapore, Singapore

6. Tan Tock Seng Hospital, Singapore, Singapore

7. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore

Abstract

Vaccination against SARS-CoV-2 induces protection through production of neutralization antibodies (nAb). The level of nAb is a major indicator of immunity against SARS-CoV-2 infection.

Funder

National Health Innovation Center

National Research Foundation Singapore

MOH | National Medical Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference33 articles.

1. High-Resolution Temporal Response Patterns to Influenza Vaccine Reveal a Distinct Human Plasma Cell Gene Signature

2. Correlation of Vaccine Responses

3. Comparison of IgG and neutralizing antibody responses after one or two doses of COVID-19 mRNA vaccine in previously infected and uninfected individuals.

4. Ministry of Health clinical practice guidelines: chronic hepatitis B infection;Chow WC;Singapore Med J,2011

5. Australian Government. n.d. Non-responders to hepatitis B vaccine are recommended to receive further doses and serological testing. The Australian Immunisation Handbook. https://immunisationhandbook.health.gov.au/recommendations/non-responders-to-hepatitis-b-vaccine-are-recommended-to-receive-further-doses-and-serological-testing. (accessed July 25 2022).

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