Stem-Loop I of the Tembusu Virus 3′-Untranslated Region Is Responsible for Viral Host-Specific Adaptation and the Pathogenicity of the Virus in Mice

Author:

Mao Li1,He Yu1,Wu Zhen1,Wang Xiaoli1,Guo Jiaqi1,Zhang Senzhao1,Wang Mingshu123,Jia Renyong123,Zhu Dekang23ORCID,Liu Mafeng123ORCID,Zhao Xinxin123,Yang Qiao123,Mao Sai123,Wu Ying123,Zhang Shaqiu123,Huang Juan123,Ou Xumin123,Gao Qun123,Sun Di123,Cheng Anchun123ORCID,Chen Shun123ORCID

Affiliation:

1. Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China

2. Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China

3. Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, China

Abstract

Mosquito-borne flaviviruses (MBFVs) constitute a large number of mosquito-transmitted viruses. The 3′-untranslated region (3′UTR) of MBFV has been suggested to be relevant to viral host-specific adaptation.

Funder

Sichuan Provincial Department of Science Technology International Scientific and Technological Innovation Cooperation

China-CEEC Joint Education Project

China Agricultural Research System

Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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