SARS-CoV-2 Inhibits NRF2-Mediated Antioxidant Responses in Airway Epithelial Cells and in the Lung of a Murine Model of Infection-Reference-Cited by-同舟云学术

SARS-CoV-2 Inhibits NRF2-Mediated Antioxidant Responses in Airway Epithelial Cells and in the Lung of a Murine Model of Infection

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Qu Yue¹,Haas de Mello Aline¹,Morris Dorothea R.¹²,Jones-Hall Yava L.³,Ivanciuc Teodora¹,Sattler Rachel A.⁴,Paessler Slobodan⁴^ORCID,Menachery Vineet D.²^ORCID,Garofalo Roberto P.¹²,Casola Antonella¹²

Affiliation:

1. Department of Pediatrics, The University of Texas Medical Branch, Galveston, Texas, USA

2. Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, USA

3. School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA

4. Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA

Abstract

The antioxidant defense system plays a major function in protecting the organism against oxidative damage caused by free radicals. COVID-19 patients often present with biochemical characteristics of uncontrolled pro-oxidative responses in the respiratory tract.

Funder

HHS | National Institutes of Health

American Association of Immunologists

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00378-23

Reference64 articles.

1. Therapeutic Modulation of Virus-Induced Oxidative Stress via the Nrf2-Dependent Antioxidative Pathway

2. Respiratory Syncytial Virus Induces Oxidative Stress by Modulating Antioxidant Enzymes