An Engineered λ Phage Enables Enhanced and Strain-Specific Killing of Enterohemorrhagic Escherichia coli-Reference-Cited by-同舟云学术

An Engineered λ Phage Enables Enhanced and Strain-Specific Killing of Enterohemorrhagic Escherichia coli

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Jin Menglu¹²,Chen Jingchao²,Zhao Xueyang¹²,Hu Guoru²,Wang Hailei¹,Liu Zhi³,Chen Wei-Hua¹²⁴^ORCID

Affiliation:

1. College of Life Science, Henan Normal University, Xinxiang, Henan, China

2. Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular Imaging, Center for Artificial Intelligence Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China

3. Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China

4. Institution of Medical Artificial Intelligence, Binzhou Medical University, Yantai, China

Abstract

Pathogenic strains of Escherichia coli are responsible for 0.8 million deaths per year and together ranked the first among all pathogenic species. Here, we obtained, for the first time, an engineered phage, Eλ, that could specifically and efficiently eliminate EHEC, one of the most common and often lethal pathogens that can spread from person to person.

Funder

National Natural Science Foundation of China

NNSF-VR Sino-Swedish Joint Research Programme

MOST | National Key Research and Development Program of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01271-22

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1. Antibiotics: past, present and future