Tracing the evolving dynamics and research hotspots of microbiota and immune microenvironment from the past to the new era
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Published:2023-10-17
Issue:5
Volume:11
Page:
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ISSN:2165-0497
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Container-title:Microbiology Spectrum
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language:en
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Short-container-title:Microbiol Spectr
Author:
Huang Runzhi1, Yao Yuntao2ORCID, Tong Xirui1, Wang Lei3, Qian Weijin2, Lu Jianyu1, Zhang Wei1, Liu Yifan2, Wang Siqiao4, Xian Shuyuan4, Zhu Yushu1, Huang Jie1, Guo Xinya1, Gu Minyi1, Lv Hanlin3, Bi Wenshuai3, Meng Chenwei3, Chang Zhengyan5ORCID, Zhang Jie6ORCID, Xu Dayuan1ORCID, Ji Shizhao1ORCID
Affiliation:
1. Department of Burn Surgery, First Affiliated Hospital of Naval Medical University, and Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences , Shanghai, China 2. Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University , Shanghai, China 3. Beijing Genomics Institute (BGI) , Shenzhen, China 4. Tongji University School of Medicine, Tongji University , Shanghai, China 5. Department of Pathology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine , Shanghai, China 6. Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopaedic Department of Tongji Hospital, School of Medicine, Tongji University , Shanghai, China
Abstract
ABSTRACT
Gut microbiota can regulate many physiological processes within gastrointestinal tract and other distal sites. Dysbiosis may not only influence chronic diseases like the inflammatory bowel disease (IBD), metabolic disease, tumor and its therapeutic efficacy, but also deteriorate acute injuries. This article aims to review the documents in this field and summarize the research hotspots as well as developing processes. Gut microbiota and immune microenvironment-related documents from 1976 to 2022 were obtained from the Web of Science Core Collection database. Bibliometrics was used to assess the core authors and journals, most contributive countries and affiliations together with hotspots in this field and keyword co-occurrence analysis. Data were visualized to help comprehension. Nine hundred and twelve documents about gut microbiota and immune microenvironment were retrieved, and the annual publications increased gradually. The most productive author, country, and affiliation were “Zitvogel L,” USA and “UNIV TEXAS MD ANDERSON CANC CTR,” respectively. FRONTIERS IN IMMUNOLOGY, CANCERS, and INTERNATIONAL JOURNAL OF MOLECULAR SCIENCE were the periodicals with most publications. Keyword co-occurrence analysis identified three clusters, including gut microbiota, inflammation, and IBD. Combined with the visualized analysis of documents and keyword co-occurrence as well as literature reading, we recognized three key topics of gut microbiota: cancer and therapy; immunity, inflammation and IBD; acute injuries and metabolic diseases. This article revealed researches on gut microbiota and immune microenvironment were growing. More attention should be given to the latest hotspots like gut microbiota, inflammation, IBD, cancer and immunotherapy, acute traumas, and metabolic diseases.
IMPORTANCE
Gut microbiota can regulate many physiological processes within gastrointestinal tract and other distal sites. Dysbiosis may not only influence chronic diseases like inflammatory bowel disease (IBD), metabolic disease, tumor and its therapeutic efficacy, but also deteriorate acute injuries. While the application of bibliometrics in the field of gut microbiota and immune microenvironment still remains blank, which focused more on the regulation of the gut microbiota on the immune microenvironment of different kinds of diseases. Here, we intended to review and summarize the presented documents in gut microbiota and immune microenvironment field by bibliometrics. And we revealed researches on gut microbiota and immune microenvironment were growing. More attention should be given to the latest hotspots like gut microbiota, inflammation, IBD, cancer and immunotherapy, acute traumas, and metabolic diseases.
Funder
MOST | National Natural Science Foundation of China
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology
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