The Practical Value of Xpert MTB/RIF Ultra for Diagnosis of Pulmonary Tuberculosis in a High Tuberculosis Burden Setting: a Prospective Multicenter Diagnostic Accuracy Study-Reference-Cited by-同舟云学术

The Practical Value of Xpert MTB/RIF Ultra for Diagnosis of Pulmonary Tuberculosis in a High Tuberculosis Burden Setting: a Prospective Multicenter Diagnostic Accuracy Study

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Wang Guirong¹,Huang Mingxiang²,Jing Hui³,Jia Junnan¹,Dong Lingling¹,Zhao Liping¹,Wang Fen¹,Xue Yi¹,Deng Yunfeng³,Jiang Guanglu¹,Huang Hairong¹^ORCID

Affiliation:

1. National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, People’s Republic of China

2. Fuzhou Pulmonary Hospital of Fujian, Fuzhou, People’s Republic of China

3. Katharine Hsu International Research Center of Human Infectious Diseases, Shandong Public Health Clinical Center, Jinan, Shandong, People’s Republic of China

Abstract

Xpert Ultra is more sensitive than Xpert, especially in smear-negative TB. A high percentage of TB history in the non-TB population did not significantly affect the reliability of the assay, which supports the potential role of Xpert Ultra as an initial diagnostic tool for TB.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00949-22

Reference24 articles.

1. World Health Organization. 2021. Global tuberculosis report 2021. Geneva, Switzerland: World Health Organization.

2. World Health Organization. 2011. Policy statement: automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB/RIF system. Geneva, Switzerland: World Health Organization.

3. Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults

4. Retrospective Analysis of False-Positive and Disputed Rifampin Resistance Xpert MTB/RIF Assay Results in Clinical Samples from a Referral Hospital in Hunan, China

5. World Health Organization. 2017. WHO meeting report for a technical expert consultation: no-inferiority analysis of Xpert MTB/RIF Ultra compared to Xpert MTB/RIF. Geneva, Switzerland: World Health Organization.

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