Caspase-Mediated Cleavage of the Transcription Factor Sp3: Possible Relevance to Cancer and the Lytic Cycle of Kaposi’s Sarcoma-Associated Herpesvirus-Reference-Cited by-同舟云学术

Caspase-Mediated Cleavage of the Transcription Factor Sp3: Possible Relevance to Cancer and the Lytic Cycle of Kaposi’s Sarcoma-Associated Herpesvirus

Published:2022-02-23 Issue:1 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Chen Li-Yu¹,Chen Lee-Wen²³,Hung Chien-Hui¹,Lin Chun-Liang⁴,Wang Shie-Shan³⁵,Chang Pey-Jium¹⁴^ORCID

Affiliation:

1. Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang-Gung University, Taoyuan, Taiwan

2. Department of Respiratory Care, Chang-Gung University of Science and Technology, Chiayi, Taiwan

3. Department of Pediatric Surgery, Chang-Gung Memorial Hospital, Chiayi, Taiwan

4. Department of Nephrology, Chang-Gung Memorial Hospital, Chiayi, Taiwan

5. School of Medicine, Chang-Gung University, Taoyuan, Taiwan

Abstract

The ORF50 protein of Kaposi’s sarcoma-associated herpesvirus (KSHV) is the key viral protein that controls the switch from latency to lytic reactivation. It is a potent transactivator that can activate target gene promoters via interacting with other cellular DNA-binding transcription factors, such as Sp3.

Funder

Chang Gung Medical Foundation | Chiayi Chang Gung Memorial Hospital

Ministry of Science and Technology, Taiwan

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01464-21

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