Single-Cell Profiling of Latently SIV-Infected CD4 <sup>+</sup> T Cells Directly <i>Ex Vivo</i> to Reveal Host Factors Supporting Reservoir Persistence-Reference-Cited by-同舟云学术

Single-Cell Profiling of Latently SIV-Infected CD4 ⁺ T Cells Directly Ex Vivo to Reveal Host Factors Supporting Reservoir Persistence

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Tokarev Andrey¹²,Machmach Kawthar¹²,Creegan Matthew¹²,Kim Dohoon¹²,Eller Michael A.¹²,Bolton Diane L.¹²

Affiliation:

1. US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA

2. The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA

Abstract

Effective combination antiretroviral therapy controls HIV-1 infection but fails to eliminate latent viral reservoirs that give rise to viremia upon treatment interruption. Strategies to eradicate latently infected cells require a better understanding of their biology and distinguishing features to promote their elimination.

Funder

U.S. Department of Defense

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00604-22

Reference83 articles.

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5. The Remarkable Stability of the Latent Reservoir for HIV-1 in Resting Memory CD4+T Cells

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