The Candida glabrata Parent Strain Trap: How Phenotypic Diversity Affects Metabolic Fitness and Host Interactions-Reference-Cited by-同舟云学术

The Candida glabrata Parent Strain Trap: How Phenotypic Diversity Affects Metabolic Fitness and Host Interactions

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Usher Jane¹^ORCID,Ribeiro Gabriela F.²^ORCID,Childers Delma S.²^ORCID

Affiliation:

1. Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, United Kingdom

2. University of Aberdeen, Institute of Medical Sciences, Aberdeen Fungal Group, Aberdeen, United Kingdom

Abstract

Reference strains provide essential insights into the mechanisms underlying virulence in fungal pathogens. However, recent studies in Candida albicans and other species have revealed significant genotypic and phenotypic diversity within clinical isolates that are challenging paradigms regarding key virulence factors and their regulation. Candida glabrata is the second leading cause of candidiasis, and many studies use BG2 or CBS138 for their investigations.

Funder

UKRI | Biotechnology and Biological Sciences Research Council

Medical Research Council Centre for Medical Mycology

Academy of Medical Sciences

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03724-22

Reference60 articles.

1. A novel small molecule inhibitor of Candida albicans biofilm formation, filamentation and virulence with low potential for the development of resistance