Targeted Metabolomics and High-Throughput RNA Sequencing-Based Transcriptomics Reveal Massive Changes in the Streptomyces venezuelae NRRL B-65442 Metabolism Caused by Ethanol Shock-Reference-Cited by-同舟云学术

Targeted Metabolomics and High-Throughput RNA Sequencing-Based Transcriptomics Reveal Massive Changes in the Streptomyces venezuelae NRRL B-65442 Metabolism Caused by Ethanol Shock

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Sekurova Olga N.¹,Zehl Martin²,Predl Michael³⁴,Hunyadi Peter³,Rattei Thomas³⁴,Zotchev Sergey B.¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, Division of Pharmacognosy, University of Vienna, Vienna, Austria

2. Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria

3. University of Vienna, Centre for Microbiology and Environmental Systems Science, Division of Computational System Biology, Vienna, Austria

4. University of Vienna, Doctoral School in Microbiology and Environmental Science, Vienna, Austria

Abstract

Streptomyces spp. are filamentous Gram-positive bacteria known as versatile producers of secondary metabolites, of which some have been developed into human medicines against infections and cancer. The genomes of these bacteria harbor dozens of gene clusters governing the biosynthesis of secondary metabolites (BGCs), of which most are not expressed under laboratory conditions.

Funder

Austrian Science Fund

Universität Wien

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03672-22

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