Density Analysis of Enterovirus D68 Shows Viral Particles Can Associate with Exosomes-Reference-Cited by-同舟云学术

Density Analysis of Enterovirus D68 Shows Viral Particles Can Associate with Exosomes

Published:2022-02-23 Issue:1 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Rudy Michael J.¹^ORCID,Coughlan Christina¹²³,Hixon Alison M.⁴,Clarke Penny¹,Tyler Kenneth L.¹⁵⁶⁷^ORCID

Affiliation:

1. Department of Neurology, University of Colorado, Aurora, Colorado, USA

2. University of Colorado Alzheimer’s and Cognition Center, Aurora, Colorado, USA

3. Linda Crnic Institute for Down Syndrome, Aurora, Colorado, USA

4. Medical Scientist Training Program, University of Colorado, Aurora, Colorado, USA

5. Department of Immunology and Microbiology, University of Colorado, Aurora, Colorado, USA

6. Division of Infectious Disease, Department of Medicine, University of Colorado, Aurora, Colorado, USA

7. VA Medical Center, Aurora, Colorado, USA

Abstract

Despite the strong causal link between enterovirus D68 (EV-D68) and acute flaccid myelitis (AFM), it remains unclear how EV-D68 gains entry into the central nervous system and what receptors enable it to infect motor neurons. We show that EV-D68 particles can adhere to exosomes, placing EV-D68 among a handful of other picornaviruses which are known to interact with extracellular vesicles.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02452-21

Reference28 articles.

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3. Worldwide emergence of multiple clades of enterovirus 68