Enterovirus D68 VP3 Targets the Interferon Regulatory Factor 7 To Inhibit Type I Interferon Response-Reference-Cited by-同舟云学术

Enterovirus D68 VP3 Targets the Interferon Regulatory Factor 7 To Inhibit Type I Interferon Response

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Kang Jun¹²,Huang Mengqian¹²^ORCID,Li Jinyu¹,Zhang Keke¹,Zhu Cheng¹²,Liu Sihua¹²,Zhou Zhenwei¹,Wang Tao¹²^ORCID,Wang Zhiyun³

Affiliation:

1. School of Life Sciences, Tianjin University, Tianjin, China

2. Institute of Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, Tianjin, China

3. School of Environmental Science and Engineering, Tianjin University, Tianjin, China

Abstract

EV-D68 is a globally emerging pathogen that causes severe respiratory illnesses. Here, we report that EV-D68 inhibits innate immune responses by targeting IRF7. Further investigations revealed that the structural protein VP3 inhibited the TRAF6-induced ubiquitination of IRF7 by competitive interaction with IRF7. These results indicate that the control of IRF7 by VP3 may be a mechanism by which EV-D68 represses IFN-I production.

Funder

National Natural Science Foundation of China

MOST | National Key Research and Development Program of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04138-22

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