Liver-Humanized NSG-PiZ Mice Support the Study of Chronic Hepatitis B Virus Infection and Antiviral Therapies-Reference-Cited by-同舟云学术

Liver-Humanized NSG-PiZ Mice Support the Study of Chronic Hepatitis B Virus Infection and Antiviral Therapies

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Colón-Thillet Rossana¹,Stone Daniel¹^ORCID,Loprieno Michelle A.¹,Klouser Lindsay¹,Roychoudhury Pavitra¹²^ORCID,Santo Tracy K.²,Xie Hong²,Stensland Laurence²,Upham Sarah L.²,Pepper Gregory²,Huang Meei-Li²,Aubert Martine¹,Jerome Keith R.¹²

Affiliation:

1. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA

2. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA

Abstract

Liver-humanized mouse models have become the gold standard for the in vivo study of hepatitis B virus (HBV), yet their complexity and cost have prohibited widespread use of existing models in research. Here, we show that the NSG-PiZ liver-humanized mouse model, which is relatively inexpensive and simple to establish, can support chronic HBV infection.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Cancer Institute

Washington Research Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.05176-22

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