Mycobiome Study Reveals Different Pathogens of Vulvovaginal Candidiasis Shape Characteristic Vaginal Bacteriome

Author:

Zhao Changying123,Li Ying4,Chen Bin12,Yue Kaile12,Su Zhenzhen12,Xu Jing4,Xue Wanhua4,Zhao Guoping1256,Zhang Lei1235ORCID

Affiliation:

1. Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China

2. Microbiome-X, National Institute of Health Data Science of China, Cheeloo College of Medicine, Shandong University, Jinan, China

3. Shandong Children’s Microbiome Center, Children’s Hospital affiliated with Shandong University, Jinan, China

4. Qilu Hospital of Shandong University Dezhou Hospital & Dezhou People's Hospital, Dezhou, China

5. State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China

6. CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

Abstract

Fungi headed by C. albicans play a critical role in VVC but are not sufficient for its occurrence, indicating the involvement of other factors, such as the vaginal bacteriome. We found that different CST correspond to different bacterial composition in patients with VVC, and this could underlie the alteration of vaginal microorganism environment in VVC patients.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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