Glucose Induces Resistance to Polymyxins in High-Alcohol-Producing Klebsiella pneumoniae via Increasing Capsular Polysaccharide and Maintaining Intracellular ATP

Author:

Fan Zheng1,Fu Tongtong1,Liu Hongbo2,Li Zhoufei1,Du Bing3,Cui Xiaohu1,Zhang Rui14,Feng Yanling1,Zhao Hanqing1,Xue Guanhua1,Cui Jinghua1,Yan Chao1,Gan Lin1,Feng Junxia1,Xu Ziying1,Yu Zihui1,Tian Ziyan1,Ding Zanbo1,Chen Jinfeng1,Chen Yujie1,Yuan Jing1ORCID

Affiliation:

1. Department of Bacteriology, Capital Institute of Pediatrics, Beijing, China

2. School of Pharmaceutical Sciences, Jilin University, Changchun, China

3. University of Edinburgh, Edinburgh, United Kingdom

4. Graduate School, Peking Union Medical College, Beijing, China

Abstract

HiAlc Kpn can use glucose to produce excess endogenous alcohol for promoting the development of NAFLD. Polymyxins are the last line of antibiotics and are commonly used to treat infections caused by carbapenem-resistant K. pneumoniae .

Funder

MOST | National Natural Science Foundation of China

Natural Science Foundation of Beijing Municipality

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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