Isocitrate Lyase (AceA) Is Required for Salmonella Persistence but Not for Acute Lethal Infection in Mice-Reference-Cited by-同舟云学术

Isocitrate Lyase (AceA) Is Required for Salmonella Persistence but Not for Acute Lethal Infection in Mice

Published:2005-04 Issue:4 Volume:73 Page:2547-2549
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Fang Ferric C.¹,Libby Stephen J.¹,Castor Margaret E.¹,Fung Angela M.¹

Affiliation:

1. Departments of Laboratory Medicine and Microbiology, University of Washington School of Medicine, Seattle, Washington

Abstract

ABSTRACT Isocitrate lyase is required for fatty acid utilization via the glyoxylate shunt. Although isocitrate lyase is essential for Salmonella persistence during chronic infection, it is dispensable for acute lethal infection in mice. Substrate availability in the phagosome appears to evolve over time, with increasing fatty acid dependence during chronic infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.73.4.2547-2549.2005

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