Conformational Changes and Nuclear Entry of Porcine Circovirus without Disassembly-Reference-Cited by-同舟云学术

Conformational Changes and Nuclear Entry of Porcine Circovirus without Disassembly

Published:2019-10-15 Issue:20 Volume:93 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Wang Huijuan¹,Zhang Kailun¹,Lin Cui¹,Zhou Jianwei¹,Jin Yulan¹,Dong Weiren¹,Gu Jinyan¹,Zhou Jiyong¹²

Affiliation:

1. MOA Key Laboratory of Animal Virology and Department of Veterinary Medicine, Zhejiang University, Hangzhou, China

2. Collaborative Innovation Center and State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, Zhejiang University, Hangzhou, China

Abstract

Circovirus is the smallest virus known to replicate autonomously. Knowledge of viral genome release may provide understanding of viral replication and a method to artificially inactivate viral particles. Currently, little is known about the release model of porcine circovirus type 2 (PCV2). Here, we report the release of the PCV2 genome from assembled capsid and the intracellular trafficking of infectious PCV2 by alterations in the capsid conformation. Knowledge of PCV2 capsid stability and dynamics is essential to understanding its infectious cycle and lays the foundation for discovering powerful targets for therapeutic and prophylactic intervention.

Funder

National Key S & T Development Program of China

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00824-19

Reference39 articles.

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2. Comparison of the Structures of Three Circoviruses: Chicken Anemia Virus , Porcine Circovirus Type 2 , and Beak and Feather Disease Virus