Emergence of Linezolid-Resistant Mutants in a Susceptible-Cell Population of Methicillin-Resistant Staphylococcus aureus-Reference-Cited by-同舟云学术

Emergence of Linezolid-Resistant Mutants in a Susceptible-Cell Population of Methicillin-Resistant Staphylococcus aureus

Published:2011-05 Issue:5 Volume:55 Page:2466-2468
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ikeda-Dantsuji Yurika¹,Hanaki Hideaki¹,Nakae Taiji¹,Takesue Yoshio²,Tomono Kazunori³,Honda Junichi⁴,Yanagihara Katsunori⁵,Mikamo Hiroshige⁶,Fukuchi Kunihiko⁷,Kaku Mitsuo⁸,Kohno Shigeru⁹,Niki Yoshihito¹⁰

Affiliation:

1. Laboratory for Antimicrobial Agents, Kitasato University, Tokyo

2. Department of Infection Control and Prevention, Hyogo College of Medicine, Hyogo

3. Department of Clinical Infectious Disease, Osaka University School of Medicine, Osaka

4. Department of Infection Control, St. Mary's Hospital, Fukuoka

5. Department of Laboratory Medicine, Nagasaki University School of Medicine, Nagasaki

6. Department of Infection Control and Prevention, Aichi Medical University, Aichi

7. Department of Laboratory Medicine, Showa University School of Medicine, Tokyo

8. Department of Infection Control and Laboratory Diagnostics, Internal Medicine, Tohoku University Graduate School of Medicine, Miyagi

9. Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki

10. Department of Clinical Infectious Disease, Showa University School of Medicine, Tokyo, Japan

Abstract

ABSTRACT Methicillin-resistant Staphylococcus aureus with a MIC of linezolid of 4 μg/ml, isolated from a patient who had undergone unsuccessful linezolid therapy, yielded linezolid-resistant mutants in blood agar at 48 h of incubation. The resistant clones showed a MIC of linezolid ranging from 8 to 64 μg/ml and accumulated the T2500A mutation(s) of the rRNA genes. Emergence of these resistant clones appears to be facilitated by a cryptic mutation or mutations associated with chloramphenicol resistance.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01548-10

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