Properties of Plasmodium falciparum with a Deleted Apicoplast DNA Gyrase-Reference-Cited by-同舟云学术

Properties of Plasmodium falciparum with a Deleted Apicoplast DNA Gyrase

Published:2021-08-17 Issue:9 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Tan SooNee¹,Mudeppa Devaraja G.¹,Kokkonda Sreekanth¹,White John¹,Patrapuvich Rapatbhorn¹²,Rathod Pradipsinh K.¹

Affiliation:

1. Department of Chemistry, University of Washington, Seattle, Washington, USA

2. Drug Research Unit for Malaria, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Abstract

Malaria parasites have three genomes: a nuclear genome, a mitochondrial genome, and an apicoplast genome. Since the apicoplast is a plastid organelle of prokaryotic origin and has no counterpart in the human host, it can be a source of novel targets for antimalarials. Plasmodium falciparum DNA gyrase ( Pf Gyr) A and B subunits both have apicoplast-targeting signals.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00586-21

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