Antibacterial Activities of Iron Chelators against Common Nosocomial Pathogens-Reference-Cited by-同舟云学术

Antibacterial Activities of Iron Chelators against Common Nosocomial Pathogens

Published:2012-10 Issue:10 Volume:56 Page:5419-5421
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Thompson Mitchell G.¹,Corey Brendan W.¹,Si Yuanzheng¹,Craft David W.¹,Zurawski Daniel V.¹

Affiliation:

1. Walter Reed Army Institute of Research, Silver Spring, Maryland, USA

Abstract

ABSTRACT The activities of iron chelators (deferoxamine, deferiprone, Apo6619, and VK28) were evaluated against type strains of Acinetobacter baumannii , Pseudomonas aeruginosa , Staphylococcus aureus , Klebsiella pneumoniae , and Escherichia coli . Deferiprone, Apo6619, and VK28 each inhibited growth in standard and RPMI tissue culture medium, while deferoxamine had no effect. Additionally, time-kill assays revealed that VK28 had a bacteriostatic effect against S. aureus . Therefore, these newly developed iron chelators might provide a nontraditional approach for treatment of bacterial infections.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01197-12

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