Mycobacterial Lipomannan Induces Matrix Metalloproteinase-9 Expression in Human Macrophagic Cells through a Toll-Like Receptor 1 (TLR1)/TLR2- and CD14-Dependent Mechanism-Reference-Cited by-同舟云学术

Mycobacterial Lipomannan Induces Matrix Metalloproteinase-9 Expression in Human Macrophagic Cells through a Toll-Like Receptor 1 (TLR1)/TLR2- and CD14-Dependent Mechanism

Published:2005-10 Issue:10 Volume:73 Page:7064-7068
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Elass Elisabeth¹,Aubry Laëtitia¹,Masson Maryse¹,Denys Agnès¹,Guérardel Yann¹,Maes Emmanuel¹,Legrand Dominique¹,Mazurier Joël¹,Kremer Laurent²

Affiliation:

1. Unité de Glycobiologie Structurale et Fonctionnelle, Unité Mixte de Recherche no. 8576 du Centre National de la Recherche Scientifique, Institut Fédératif de Recherche 118, Université des Sciences et Technologies de Lille, 59655 Villeneuve d'Ascq cedex

2. Laboratoire de Dynamique Moléculaire des Interactions Membranaires, UMR CNRS no. 5539, Université des Sciences et Techniques du Languedoc (Montpellier II), 34095 Montpellier Cedex 5, France

Abstract

ABSTRACT Lipomannans (LM) from various mycobacterial species were found to induce expression and secretion of the matrix metalloproteinase 9 (MMP-9) both in human macrophage-like differentiated THP-1 cells and in primary human macrophages. Inhibition studies using antireceptor-neutralizing antibodies are indicative of a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent signaling mechanism. Moreover, LM was shown to down-regulate transcription of the metalloproteinase inhibitor TIMP-1, a major endogenous MMP-9 regulator.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.73.10.7064-7068.2005

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