Dissociation of the ampicillin-induced lysis of amino acid-deprived Escherichia coli into two stages

Author:

Pisabarro A G1,De Pedro M A1,Ishiguro E E1

Affiliation:

1. Department of Biochemistry and Microbiology, University of Victoria, British Columbia, Canada.

Abstract

The ampicillin-induced lysis of amino acid-deprived relA+ Escherichia coli was dissociated into two separate stages. The early stage ("priming") requiring the presence of ampicillin apparently involved the interaction of ampicillin with a target penicillin-binding protein. The later stage ("lysis induction") was ampicillin independent and required only chloramphenicol to relax the RelA-dependent control of peptidoglycan hydrolase activity.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference12 articles.

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