Dependence of Echovirus 9 on the Enterovirus RNA Replication Inhibitor 2-(α-Hydroxybenzyl)-Benzimidazole Maps to Nonstructural Protein 2C-Reference-Cited by-同舟云学术

Dependence of Echovirus 9 on the Enterovirus RNA Replication Inhibitor 2-(α-Hydroxybenzyl)-Benzimidazole Maps to Nonstructural Protein 2C

Published:1999-12 Issue:12 Volume:73 Page:10536-10539
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Hadaschik Dirk¹,Klein Marcus¹,Zimmermann Holger¹,Eggers Hans J.¹,Nelsen-Salz Birgit¹

Affiliation:

1. Institut für Virologie der Universität zu Köln, 50935 Cologne, Germany

Abstract

ABSTRACT HBB [2-(α-hydroxybenzyl)-benzimidazole] selectively inhibits RNA synthesis of most enteroviruses. However, isolation of HBB-dependent variants is possible. Sequence analysis and characterization of recombinant viruses revealed that HBB dependence maps to the nonstructural protein 2C. A single point mutation at position C 4782 U is sufficient to establish the HBB-dependent phenotype in our echovirus 9 model.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.73.12.10536-10539.1999

Reference24 articles.

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