Protection against Brucella abortus in mice with O-polysaccharide-specific monoclonal antibodies

Author:

Montaraz J A,Winter A J,Hunter D M,Sowa B A,Wu A M,Adams L G

Abstract

Mice injected with either of two monoclonal antibodies specific for the O polysaccharide of Brucella abortus prior to challenge infection had viable counts in spleens and livers significantly below those in control groups 1 and 4 weeks later. Two monoclonal antibodies specific for the porin of B. abortus failed to confer protection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference25 articles.

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2. Anonymous. 1965. Supplemental: test procedures for the diagnosis of brucellosis. Diagnostic reagents manual 65D E & F. Veterinary Services Laboratory U.S. Department of Agriculture Animal and Plant Health Inspection Service Ames Iowa.

3. Studies on the immune protection to murine experimental brucellosis conferred by Brucella fractions. I. Positive role of immune serum;Bascoul S.;Immunology,1978

4. Studies on the pathology and pathogenesis of experimental brucellosis. II. The formation of the hepatic granuloma and its evolution;Braude A. I.;J. Infect. Dis.,1951

5. Evaluation of the enzyme-linked immunosorbent assay for detecting Brucella abortus antibodies;Byrd J. W.;Am. J. Vet. Res.,1979

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