The stem-loop structure at the 3' end of histone mRNA is necessary and sufficient for regulation of histone mRNA stability

Author:

Pandey N B1,Marzluff W F1

Affiliation:

1. Department of Chemistry, Florida State University, Tallahassee 32306.

Abstract

Chimeric genes were made by fusing mouse histone genes with a human alpha-globin gene. The genes were introduced into mouse L cells and the stability of the chimeric mRNAs was measured when DNA synthesis was inhibited. An mRNA containing all the globin coding sequences and the last 30 nucleotides of the histone mRNA was degraded at the same rate as histone mRNA.

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Reference23 articles.

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5. Expression of mouse histone genes: transcription into 3' intergenic DNA and cryptic processing sites downstream from the 3' end of the H3 gene;Chodchoy N.;Mol. Cell. Biol.,1987

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