M-Protein Analysis of Streptococcus pyogenes Isolates Associated with Acute Rheumatic Fever in New Zealand

Author:

Williamson Deborah A.123,Smeesters Pierre R.45,Steer Andrew C.45,Steemson John D.6,Ng Adrian C. H.6,Proft Thomas27,Fraser John D.27,Baker Michael G.3,Morgan Julie1,Carter Philip E.1,Moreland Nicole J.26

Affiliation:

1. Institute of Environmental Science and Research, Wellington, New Zealand

2. Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand

3. University of Otago, Wellington, New Zealand

4. Murdoch Childrens Research Institute, Melbourne, Australia

5. Center for International Child Health, University of Melbourne, Australia

6. School of Biological Sciences, University of Auckland, Auckland, New Zealand

7. School of Medical Sciences, University of Auckland, Auckland, New Zealand

Abstract

ABSTRACT We applied an emm cluster typing system to group A Streptococcus strains in New Zealand, including those associated with acute rheumatic fever (ARF). We observed few so-called rheumatogenic emm types but found a high proportion of emm types previously associated with pyoderma, further suggesting a role for skin infection in ARF.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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