Genotypic Diversity of Coagulase-Negative Staphylococci Causing Endocarditis: a Global Perspective

Author:

Petti Cathy A.12,Simmon Keith E.2,Miro Jose M.3,Hoen Bruno4,Marco Francesc3,Chu Vivian H.5,Athan Eugene6,Bukovski Suzana7,Bouza Emilio8,Bradley Suzanne9,Fowler Vance G.5,Giannitsioti Efthymia10,Gordon David11,Reinbott Porl12,Korman Tony13,Lang Selwyn14,Garcia-de-la-Maria Cristina3,Raglio Annibale15,Morris Arthur J.16,Plesiat Patrick4,Ryan Suzanne17,Doco-Lecompte Thanh18,Tripodi Francesca19,Utili Riccardo19,Wray Dannah20,Federspiel J. Jeffrey5,Boisson K.4,Reller L. Barth5,Murdoch David R.21,Woods Christopher W.522

Affiliation:

1. Departments of Medicine and Pathology, University of Utah School of Medicine, Salt Lake City, Utah

2. ARUP Laboratories, Salt Lake City, Utah

3. Hospital Clinic Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain

4. University Medical Center of Besançon, Besançon, France

5. Duke University Medical Center

6. Barwon Health, Geelong, Australia

7. University Hospital for Infectious Disease, Zagreb, Croatia

8. Hospital General Universitario Gregorio Marañón, Madrid, Spain

9. Veterans Administration Medical Center, Ann Arbor, Michigan

10. Attikon University General Hospital, Athens, Greece

11. Flinders Medical Centre, Adelaide, Australia

12. The University of South Wales, Sydney, Australia

13. Southern Health, Clayton, Australia

14. Middlemore Hospital, Auckland, New Zealand

15. Ospedali Riuniti di Bergamo, Bergamo, Italy

16. Auckland City Hospital, Auckland, New Zealand

17. South Eastern Sydney and Illawarra Area Health Service, Australia

18. CHU Nancy-Brabois, Nancy, France

19. Second University of Naples, Naples, Italy

20. Medical University of South Carolina, Charleston, South Carolina

21. University of Otago, Christchurch, New Zealand

22. Veterans Administration Medical Center, Durham, North Carolina

Abstract

ABSTRACT Coagulase-negative staphylococci (CNS) are important causes of infective endocarditis (IE), but their microbiological profiles are poorly described. We performed DNA target sequencing and susceptibility testing for 91 patients with definite CNS IE who were identified from the International Collaboration on Endocarditis—Microbiology, a large, multicenter, multinational consortium. A hierarchy of gene sequences demonstrated great genetic diversity within CNS from patients with definite endocarditis that represented diverse geographic regions. In particular, rpoB sequence data demonstrated unique genetic signatures with the potential to serve as an important tool for global surveillance.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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