Genital Human Papillomavirus Genotypes in Northwestern Tanzania

Author:

Mayaud Philippe1,Weiss Helen A.1,Lacey Charles J. N.2,Gill Dilbinder K.2,Mabey David C. W.1

Affiliation:

1. Department of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT

2. Faculty of Medicine, Imperial College London, London W2 1PG, United Kingdom

Abstract

ABSTRACT Using MY09-MY11 PCR and human papillomavirus (HPV) typing by reverse blot hybridization, we found a 34% cervical HPV prevalence among 561 pregnant women in Tanzania. One hundred three of 123 women (84%) with typeable samples harbored high-risk oncogenic strains. HPV type 16 (HPV-16) was the most prevalent subtype (18%) among HPV-infected women and among women with cervical neoplasia (3 of 19). A multivalent vaccine for HPV-16, -18, -31, -33, and -35 would be necessary to prevent 50% of the neoplasia in this population.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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