Declining Growth Rate of West Nile Virus in North America

Author:

Snapinn Katherine W.1,Holmes Edward C.12,Young David S.3,Bernard Kristen A.34,Kramer Laura D.34,Ebel Gregory D.5

Affiliation:

1. Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802

2. Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892

3. The Arbovirus Laboratories, Wadsworth Center, New York State Department of Health, 5668 State Farm Rd., Slingerlands, New York 12159

4. Department of Biomedical Sciences, School of Public Health, The University at Albany, State University of New York, Albany, New York 12144-3456

5. Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131

Abstract

ABSTRACT To determine the demographic history of West Nile virus (WNV) in North America, we employed a coalescent method to envelope coding region data sets for the NY99 and WN02 genotypes. Although the observed genetic diversities in both genotypes were of approximately the same age, the mean rate of epidemiological growth of the WN02 population was approximately three times that of the NY99 population, a finding compatible with the recent dominance of the former genotype. However, there has also been a marked decrease in the recent growth rate of WN02, suggesting that WNV has reached its peak prevalence in North America.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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