Mucosal and Systemic Antibody Responses in Humans Infected with Simian Foamy Virus-Reference-Cited by-同舟云学术

Mucosal and Systemic Antibody Responses in Humans Infected with Simian Foamy Virus

Published:2005-10-15 Issue:20 Volume:79 Page:13186-13189
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Cummins James E.¹,Boneva Roumiana S.¹,Switzer William M.¹,Christensen Logan L.¹,Sandstrom Paul²,Heneine Walid¹,Chapman Louisa E.¹,Dezzutti Charlene S.¹

Affiliation:

1. HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333

2. Bureau of HIV/AIDS, STD, and TB, Centre for Infectious Disease Prevention and Control, Health Canada, Ottawa, Ontario, Canada

Abstract

ABSTRACT Simian foamy virus (SFV) infection and the subsequent immune response are not well characterized. Blood plasma, saliva, and urine were obtained from four humans and nine chimpanzees persistently infected with chimpanzee-type SFV for an unknown length of time. SFV-specific immunoglobulin G (IgG) antibodies, but not IgA antibodies, against the Gag and Bet proteins were detected, by Western blotting, in all sample types from infected humans and chimpanzees. Overall, chimpanzee samples had higher anti-SFV IgG titers than humans. These results provide a first comparative evaluation of SFV-specific host mucosal humoral immunity in infected humans and chimpanzees that is characterized by a predominant IgG response and a virtually absent IgA response.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.79.20.13186-13189.2005

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