Candidalysins Are a New Family of Cytolytic Fungal Peptide Toxins-Reference-Cited by-同舟云学术

Candidalysins Are a New Family of Cytolytic Fungal Peptide Toxins

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
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Author:

Richardson Jonathan P.¹^ORCID,Brown Rhys¹,Kichik Nessim¹,Lee Sejeong¹^ORCID,Priest Emily¹,Mogavero Selene²^ORCID,Maufrais Corinne³⁴,Wickramasinghe Don N.¹,Tsavou Antzela¹,Kotowicz Natalia K.¹,Hepworth Olivia W.¹,Gallego-Cortés Ana¹,Ponde Nicole O.¹,Ho Jemima¹,Moyes David L.¹,Wilson Duncan⁵,D’Enfert Christophe⁴^ORCID,Hube Bernhard²⁶^ORCID,Naglik Julian R.¹

Affiliation:

1. Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King’s College London, London, United Kingdom

2. Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany

3. Institut Pasteur, Université de Paris, Bioinformatics and Biostatistics Hub, Paris, France

4. Institut Pasteur, Université de Paris, INRAE, USC2019, Unité Biologie et Pathogénicité Fongiques, Paris, France

5. Medical Research Council Centre for Medical Mycology at the University of Exeter, Exeter, United Kingdom

6. Institute of Microbiology, Friedrich Schiller University, Jena, Germany

Abstract

Pathogenic fungi kill an estimated 1.5 million people every year. Recently, we discovered that the fungal pathogen Candida albicans secretes a peptide toxin called candidalysin during mucosal infection.

Funder

NIH Research at Guy's and St. Thomas's NHS Foundation Trust and the King's College London Biomedical Research Centre

MRC and University of Exeter

Deutsche Forschungsgemeinschaft

Investissement d'Avenir program

HHS | National Institutes of Health

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

UKRI | Biotechnology and Biological Sciences Research Council

Wellcome Trust

Publisher

American Society for Microbiology

Subject