Diversification by CofC and Control by CofD Govern Biosynthesis and Evolution of Coenzyme F <sub>420</sub> and Its Derivative 3PG-F <sub>420</sub>-Reference-Cited by-同舟云学术

Diversification by CofC and Control by CofD Govern Biosynthesis and Evolution of Coenzyme F ₄₂₀ and Its Derivative 3PG-F ₄₂₀

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Hasan Mahmudul¹,Schulze Sabrina²,Berndt Leona²,Palm Gottfried J.²,Braga Daniel¹,Richter Ingrid³,Last Daniel¹^ORCID,Lammers Michael²^ORCID,Lackner Gerald¹^ORCID

Affiliation:

1. Junior Research Group Synthetic Microbiology, Leibniz-Institute for Natural Product Research and Infection Biology, Jena, Germany

2. Institute of Biochemistry, Dep. Synthetic and Structural Biochemistry, Felix-Hausdorff-Str. 4, University of Greifswald, Greifswald, Germany

3. Dept. Biomolecular Chemistry, Leibniz-Institute for Natural Product Research and Infection Biology, Jena, Germany

Abstract

The microbial cofactor F 420 is crucial for processes like methanogenesis, antibiotics biosynthesis, drug resistance, and biocatalysis. Recently, a novel derivative of F 420 (3PG-F 420 ) was discovered, enabling the production and use of F 420 in heterologous hosts.

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03501-21

Reference52 articles.

1. The Structures and Physicochemical Properties of Organic Cofactors in Biocatalysis

2. Physiology, Biochemistry, and Applications of F 420 - and F o -Dependent Redox Reactions

3. UNUSUAL COENZYMES OF METHANOGENESIS

4. A novel F 420 ‐dependent anti‐oxidant mechanism protects M ycobacterium tuberculosis against oxidative stress and bactericidal agents

5. Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering

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