Distinct Group B Streptococcus Sequence and Capsule Types Differentially Impact Macrophage Stress and Inflammatory Signaling Responses-Reference-Cited by-同舟云学术

Distinct Group B Streptococcus Sequence and Capsule Types Differentially Impact Macrophage Stress and Inflammatory Signaling Responses

Published:2021-04-16 Issue:5 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Flaherty Rebecca A.¹,Aronoff David M.²³⁴,Gaddy Jennifer A.²³⁵^ORCID,Petroff Margaret G.¹⁶⁷,Manning Shannon D.¹^ORCID

Affiliation:

1. Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA

2. Department of Medicine, Division of Infectious Disease, Vanderbilt University Medical Center, Nashville, Tennessee, USA

3. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

4. Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

5. Tennessee Valley Healthcare System, Department of Veterans Affairs, Nashville, Tennessee, USA

6. Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, Michigan, USA

7. Cell and Molecular Biology Program, Michigan State University, East Lansing, Michigan, USA

Abstract

Group B Streptococcus (GBS) is an opportunistic bacterial pathogen that can contribute to the induction of preterm birth in colonized pregnant women and to severe neonatal disease. Many questions regarding the mechanisms that drive GBS-associated pathogenesis remain unanswered, and it is not yet clear why virulence has been observed to vary so extensively across GBS strains.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00647-20

Reference36 articles.

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3. Molecular pathogenesis of neonatal group B streptococcal infection: no longer in its infancy