Streptococcal tetracycline resistance mediated at the level of protein synthesis

Author:

Burdett V

Abstract

The mechanism of tetracycline resistance was examined in strains containing each of the three previously identified resistance determinants in Streptococcus spp. Uptake of tetracycline was measured in tetracycline-sensitive cells as well as in cells containing each of the three resistance determinants. In cells containing tetL, uptake was not observed. However, in sensitive cells and cells containing either tetM or tetN, tetracycline was accumulated approximately 25-fold against a concentration gradient. Furthermore, there was no evidence for modification of intracellular tetracycline recovered from sensitive, tetM, or tetN cells. Protein synthesis in extracts derived from organisms containing tetM or tetN was resistant to tetracycline. In contrast, extracts of sensitive and tetL cells were sensitive to tetracycline.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Cited by 125 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Tetracycline Resistance on Protein Synthesis;Biomedicine and Chemical Sciences;2023-04-01

2. Antimicrobial resistance genes in bacteria from animal-based foods;Advances in Applied Microbiology;2020

3. Pathogenic Escherichia coli: Virulence Factors and Their Antimicrobial Resistance;Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery;2020

4. Tetracycline-Inactivating Enzymes;Frontiers in Microbiology;2018-05-30

5. Tetracycline Antibiotics and Resistance;Cold Spring Harbor Perspectives in Medicine;2016-03-17

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