Binding of Thiostrepton to Ribosomes from Thiostrepton-Sensitive and -Resistant Bacillus subtilis Strains

Author:

Vince Robert,Weiss David,Gordon Julian,Howard Guy,Smith Issar,Pestka Sidney1

Affiliation:

1. Roche Institute of Molecular Biology, Nutley, New Jersey 07110

Abstract

Binding of [ 35 S]thiostrepton to ribosomes from thiostrepton-sensitive and -resistant strains of Bacillus subtilis was studied. Ribosomes from thiostrepton-resistant strains bound relatively little thiostrepton compared with ribosomes from thiostrepton-sensitive B. subtilis . In addition, ribosomes from revertant strains that were obtained as thiostrepton-sensitive revertants from thiostrepton-resistant strains bound [ 35 S]thiostrepton similarly to ribosomes from the sensitive parental strain.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Cited by 8 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Interaction Between Biomolecules Studied by Phase Partition;Methods of Biochemical Analysis;2006-10-31

2. Partitioning: A Comprehensive Bibliography;Partitioning in Aqueous Two-Phase System;1985

3. Ribosomal protein alterations in thiostrepton- and Micrococcin-resistant mutants of Bacillus subtilis.;Journal of Biological Chemistry;1979-08

4. Thiostrepton and Related Antibiotics;Mechanism of Action of Antibacterial Agents;1979

5. Thiostrepton-resistant mutants exhibit relaxed synthesis of RNA.;Proceedings of the National Academy of Sciences;1978-12-01

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