The Lymphocytic Scavenger Receptor CD5 Shows Therapeutic Potential in Mouse Models of Fungal Infection-Reference-Cited by-同舟云学术

The Lymphocytic Scavenger Receptor CD5 Shows Therapeutic Potential in Mouse Models of Fungal Infection

Published:2020-12-16 Issue:1 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Velasco-de Andrés María¹,Català Cristina¹,Casadó-Llombart Sergi¹,Martínez-Florensa Mario¹,Simões Inês¹,García-Luna Joaquín²,Mourglia-Ettlin Gustavo²,Zaragoza Óscar³,Carreras Esther¹,Lozano Francisco¹⁴⁵^ORCID

Affiliation:

1. Immunoreceptors of the Innate and Adaptive System, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain

2. Área Inmunología, Facultad de Química/Facultad de Ciencias, DEPBIO/IQB, Universidad de la República, Montevideo, Uruguay

3. Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Spain

4. Servei d’Immunologia, Centre de Diagnòstic Biomèdic, Hospital Clínic de Barcelona, Barcelona, Spain

5. Departament de Biomedicina, Universitat de Barcelona, Barcelona, Spain

Abstract

Invasive fungal diseases represent an unmet clinical need that could benefit from novel immunotherapeutic approaches. Host pattern recognition receptors (e.g., Toll-like receptors, C-type lectins, or scavenger receptors) that sense conserved fungal cell wall constituents may provide suitable immunotherapeutic antifungal agents. Thus, we explored the therapeutic potential of the lymphocyte class I scavenger receptor CD5, a nonredundant component of the antifungal host immune response that binds to fungal β-glucans.

Funder

European Commission

Ministerio de Educación, Cultura y Deporte

Agencia Nacional de Investigación e Innovación

MEC | Fundação para a Ciência e a Tecnologia

Ministerio de Economía y Competitividad

Ministerio de Economía, Industria y Competitividad, Gobierno de España

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link