Author:
Moken M C,McMurry L M,Levy S B
Abstract
Mutants of Escherichia coli selected for resistance to the disinfectant pine oil or to a household product containing pine oil also showed resistance to multiple antibiotics (tetracycline, ampicillin, chloramphenicol, and nalidixic acid) and overexpressed the marA gene. Likewise, antibiotic-selected Mar mutants, which also overexpress marA, were resistant to pine oil. Deletion of the mar or acrAB locus, the latter encoding a multidrug efflux pump positively regulated in part by MarA, increased the susceptibility of wild-type and mutant strains to pine oil.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference29 articles.
1. Molecular characterization of the soxRS genes of Escherichia coli: two genes control a superoxide stress regulon;Amabile-Cuevas C. F.;Nucleic Acids Res.,1991
2. Repressor mutations in the marRAB operon that activate oxidative stress genes and multiple antibiotic resistance in Escherichia coli;Ariza R. R.;J. Bacteriol.,1994
3. Activation of multiple antibiotic resistance and binding of stress-inducible promoters by Escherichia coli Rob protein;Ariza R. R.;J. Bacteriol.,1995
4. Ausubel F. M. R. Brent R. E. Kingston et al. (ed.). 1996. Current protocols in molecular biology vol. 1 p. 4.2.3-4.2.5. John Wiley & Sons New York N.Y.
5. Claus E. P. V. E. Tyler and L. R. Brady. 1970. Pharmacognosy. Lea and Febiger Philadelphia Pa.
Cited by
176 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献