Contribution of Host miRNA-223-3p to SARS-CoV-Induced Lung Inflammatory Pathology-Reference-Cited by-同舟云学术

Contribution of Host miRNA-223-3p to SARS-CoV-Induced Lung Inflammatory Pathology

Published:2022-04-26 Issue:2 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Morales Lucía¹,Oliveros Juan Carlos²,Enjuanes Luis¹^ORCID,Sola Isabel¹^ORCID

Affiliation:

1. Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Madrid, Spain

2. Computational Genomics Service, National Center of Biotechnology (CNB-CSIC), Madrid, Spain

Abstract

The SARS-CoV-2 pandemic has emphasized the need to understand the mechanisms of severe lung inflammatory pathology caused by human deadly coronaviruses in order to design new antiviral therapies. Here, we identify miRNA-223-3p as a host miRNA involved in the regulation of lung inflammatory response mediated by envelope (E) protein during SARS-CoV infection. miRNAs downregulate the expression of cellular mRNAs and participate in complex networks of mRNA–miRNA interactions that regulate cellular processes.

Funder

Government of Spain

Consejo superior de investigaciones científicas

European Commission

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03135-21

Reference97 articles.