Model-Based Relationship between the Molecular Bacterial Load Assay and Time to Positivity in Liquid Culture-Reference-Cited by-同舟云学术

Model-Based Relationship between the Molecular Bacterial Load Assay and Time to Positivity in Liquid Culture

Published:2019-10 Issue:10 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Svensson Robin J.¹,Sabiiti Wilber²,Kibiki Gibson S.³,Ntinginya Nyanda E.⁴,Bhatt Nilesh⁵,Davies Geraint⁶,Gillespie Stephen H.²,Simonsson Ulrika S. H.¹

Affiliation:

1. Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden

2. The School of Medicine, University of St. Andrews, St. Andrews, United Kingdom

3. East African Health Research Commission, Arusha, Tanzania

4. NIMR-Mbeya Medical Research Centre, Mbeya, Tanzania

5. Instituto Nacional de Saúde (INS), Ministério da Saúde, Maputo, Mozambique

6. Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom

Abstract

The molecular bacterial load (MBL) assay is a new tuberculosis biomarker which provides results in ∼4 hours. The relationship between MBL and time-to-positivity (TTP) has not been thoroughly studied, and predictive models do not exist. We aimed to develop a model for MBL and identify the MBL-TTP relationship in patients.

Funder

European Developing Countries Clinical Trials Partnership

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00652-19

Reference24 articles.

1. Time to positivity in liquid culture predicts colony forming unit counts of Mycobacterium tuberculosis in sputum specimens

2. A multicentre comparison of a novel surrogate marker for determining the specific potency of anti-tuberculosis drugs

3. Time to liquid culture positivity can substitute for colony counting on agar plates in early bactericidal activity studies of antituberculosis agents