Glycemic Variability in Diabetes Increases the Severity of Influenza-Reference-Cited by-同舟云学术

Glycemic Variability in Diabetes Increases the Severity of Influenza

Published:2020-04-28 Issue:2 Volume:11 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Marshall Rebecca J.¹,Armart Pornthida¹,Hulme Katina D.¹,Chew Keng Yih¹,Brown Alexandra C.²³,Hansbro Philip M.²³⁴⁵,Bloxham Conor J.⁶^ORCID,Flint Melanie⁶,Ronacher Katharina⁷,Bielefeldt-Ohmann Helle¹⁸,Gallo Linda A.⁶⁷,Short Kirsty R.¹⁸

Affiliation:

1. School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, QLD, Australia

2. Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton, NSW, Australia

3. The University of Newcastle, Callaghan, NSW, Australia

4. Centre for Inflammation, Centenary Institute, Sydney, NSW, Australia

5. University of Technology Sydney, Faculty of Science, Ultimo, NSW, Australia

6. School of Biomedical Sciences, The University of Queensland, St. Lucia, QLD, Australia

7. Mater Research Institute, Translational Research Institute, The University of Queensland, Woolloongabba, QLD, Australia

8. Australian Infectious Diseases Research Centre, The University of Queensland, St. Lucia, QLD, Australia

Abstract

Every winter, people with diabetes are at increased risk of severe influenza. At present, the mechanisms that cause this increased susceptibility are unclear. Here, we show that the fluctuations in blood glucose levels common in people with diabetes are associated with severe influenza. These data suggest that glycemic stability could become a greater clinical priority for patients with diabetes during outbreaks of influenza.

Funder

NHMRC

ARC

nhmrc

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02841-19

Reference56 articles.

1. Diabetes and the Severity of Pandemic Influenza A (H1N1) Infection