Systematic Adaptation of Bacillus licheniformis to 2-Phenylethanol Stress

Author:

Zhan Yangyang1,Xu Haixia1,Tan Hween Tong2,Ho Ying Swan2,Yang Dongxiao2,Chen Shuwen2,Ow Dave Siak-Wei2ORCID,Lv Xin3,Wei Fang3,Bi Xuezhi2,Chen Shouwen1ORCID

Affiliation:

1. State Key Laboratory of Biocatalysis and Enzyme Engineering, Environmental Microbial Technology Center of Hubei Province, College of Life Sciences, Hubei University, Wuhan, Hubei, People’s Republic of China

2. Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

3. Key Laboratory of Oilseeds Processing of Ministry of Agriculture, Hubei Key Laboratory of Lipid Chemistry and Nutrition, Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Wuhan, Hubei, People’s Republic of China

Abstract

The ability to tolerate organic solvents is essential for bacteria producing these chemicals with high titer, yield, and productivity. As exemplified by 2-PE, bioproduction of 2-PE represents a promising alternative to chemical synthesis and plant extraction approaches, but its toxicity hinders successful large-scale microbial production.

Funder

MOST | National Key Research and Development Program of China

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Reference47 articles.

1. Recent advances in biotechnological production of 2-phenylethanol

2. Advances in 2-phenylethanol production from engineered microorganisms

3. Bioprocesses for 2-phenylethanol and 2-phenylethyl acetate production: current state and perspectives

4. Production of natural 2-phenylethanol from glucose or glycerol with coupled Escherichia coli strains expressing l-phenylalanine biosynthesis pathway and artificial biocascades;Sekar BS;ACS Sustain Chem Eng,2019

5. Multilevel metabolic engineering of Bacillus licheniformis for de novo biosynthesis of 2-phenylethanol

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