Identification and Characterization of Rift Valley Fever Virus-Specific T Cells Reveals a Dependence on CD40/CD40L Interactions for Prevention of Encephalitis-Reference-Cited by-同舟云学术

Identification and Characterization of Rift Valley Fever Virus-Specific T Cells Reveals a Dependence on CD40/CD40L Interactions for Prevention of Encephalitis

Published:2021-11-09 Issue:23 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Barbeau Dominique J.¹²³^ORCID,Cartwright Haley N.¹²³^ORCID,Harmon Jessica R.⁴,Spengler Jessica R.⁴^ORCID,Spiropoulou Christina F.⁴,Sidney John⁵,Sette Alessandro⁵⁶,McElroy Anita K.¹²³^ORCID

Affiliation:

1. University of Pittsburgh School of Medicine, Department of Pediatrics, Division of Pediatric Infectious Disease, Pittsburgh, Pennsylvania, USA

2. University of Pittsburgh Center for Vaccine Research, Pittsburgh, Pennsylvania, USA

3. University of Pittsburgh, UPMC Children’s Hospital, Pittsburgh, Pennsylvania, USA

4. Centers for Disease Control and Prevention, Viral Special Pathogens Branch, Atlanta, Georgia, USA

5. Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA

6. Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, California, USA

Abstract

The prevention of RVFV encephalitis requires intact adaptive immunity. In this study, we developed reagents to detect RVFV-specific T cells and provide evidence for Tfh cells and CD40/CD40L interactions as critical mediators of this protection.

Funder

Burroughs Wellcome Fund

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01506-21

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